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#Trypanosoma musculi# infection in mice critically relies on mannose receptor¿mediated arginase induction by a #Tb#KHC1 kinesin H chain homolog

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Nzoumbou-Boko R., De Muylder G., Semballa S., Lecordier L., Dauchy F.A., Gobert A.P., Holzmuller P., Lemestre J.L., Bras-Gonçalves R., Barnabé C., Courtois P., Daulouède S., Beschin A., Pays E., Vincendeau P.
2017

Arginase activity induction in macrophages is an escape mechanism developed by parasites to cope with the host's immune defense and benefit from increased host-derived growth factor production. We report that arginase expression and activity were induced in macrophages during mouse infection by Trypanosoma musculi, a natural parasite of this host. This induction was reproduced in vitro by ...

Maladies des animaux; Organismes nuisibles des animaux

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