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Negative purifying selection drives prion and doppel protein evolution

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Tsangaras K., Kolokotronis S.O., Ulrich R.G., Morand S., Michaux J., Greenwood A.
2014

The prion protein (PrP) when misfolded into the pathogenic conformer PrPSc is the major causative agent of several lethal transmissible spongiform encephalopathies in mammals. Studies of evolutionary pressure on the corresponding gene using different datasets have yielded conflicting results. In addition, putative PrP or PrP interacting partners with strong similarity to PrP such as the doppel ...

Maladies des animaux; Autres thèmes

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