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Total synthesis and biological assessment of novel albicidins discovered by mass spectrometric networking

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Von Eckardstein L., Petras D., Cociancich S., Sabri S., Grätz S., Kerwat D., Seidel M., Pesic A., Dorrestein P.C., Royer M., Weston J.B., Süssmuth R.
2017

Natural products represent an important source of potential novel antimicrobial drug leads. Low production by microorganisms in cell culture often delays the structural elucidation or even prevents a timely discovery. Starting from the anti-Gram-negative antibacterial compound albicidin produced by Xanthomonas albilineans, we describe a bioactivity-guided approach combined with non-targeted ...

Autres thèmes; Maladies des plantes; Sciences et hygiène vétérinaires : considérations générales

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