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Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations

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Kosch T.A., Bataille A., Didinger C., Eimes J.A., Rodríguez-Brenes S., Ryan M.G., Waldman B.
2016

Pathogen-driven selection can favour major histocompatibility complex (MHC) alleles that confer immunological resistance to specific diseases. However, strong directional selection should deplete genetic variation necessary for robust immune function in the absence of balancing selection or challenges presented by other pathogens. We examined selection dynamics at one MHC class II (MHC-II) locus ...

Maladies des animaux; Physiologie et biochimie animales

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